Post

Open source rant

An early blog post about not supporting the communities that support us.

See the great thing about scienceHover imageoffend_readers.jpg and technologyHover imagecompetent_technophile.png jobs is our transparencyHover imageNotALieIfYouBelieveIt.jpg and focus on the problemHover imageWho's my boss?, not on the financeHover imagePhD in Phrama finance.... You could sayHover imageSay Anthing that the tech sector is very scientificHover imageTammyBrown.webp and rationalHover imageiKantEven.gif. You see, we rationalizeHover imageAggression... taking advantageHover imageWhy're all the good developers starving? of liberallyHover imageBuscemi.jpg licensedHover imageThereIsNoSpoon.png software.

We valueHover imageGoodGuyFSF.png open source softwareHover imageDigital Anti-trust because... it means we didn't have toHover imageHow much we value the backbone of 2018 tech write it. We express our value by not reciprocatingHover imageAt least they're competition in the Microsoft market and leveraging outside help/software to shrinkHover imageNot every exec is bad... ourHover imageM&A is so hot right now... R&DHover imageWhen capitalism has gone too far budgetHover imageWell.. something something pharma R&D blah blah... so operations doesn't yell at usHover imageHow operations/marketing thinks pharma profits are made LOL for making them money. After taking all the redit of saving money and time from our use of free and open source software, we're not given those savings back in order to augmentHover imagesocialism never works tho, so... publishHover imagePrivate Pyle has a full magazine!, and reciprocateHover imagekewl-aid. Don't get us wrong...we love transparencyHover imageNationalAnthem.png. The kind where others are transparent bu we don't have toHover imagehmm... invest in certain things on principle if it means we can tell our boss our budgets are flat or looks okay, so we can avoid supporting things we personally believe in but C suite doesn't. That's the only point I'm making... it doesn't smell good.

The only problemHover imageThe core of MS is closed-source, but the business model of Azure and MS software is tied to the nature of both open-source foundations and software licensing models to OEMs. In a sense, outsourcing the hardware through software licensing is the right decision business-wise... with F(L)OSS is that sometimes the UI is uglyHover imageYet another meme... or has longHover imageChange is an internal thing. Different things happen or transform, and music and art is a documentation of that - Matisyahu documentationHover imageDocs are a love letter that you write to your future self - Damian Conway, so we do the smart thing and pay other companiesHover imageTabbie.jpeg to dumb downHover imagetoxic, maybe? the interface or the nature of the calculations for the users. See we're scIenTistSHover imageChange my mind and areHover imageNugs not drugs reallyHover imageWhat are we gonna do today, Brain? smartHover image#1. There's moar. Too smartHover imageuhhh... to waste time with rtfm or articulateHover image#2. Well... things worked out i guess..../s what features we must have or whyHover image#3. I wasnt articulate or accomplished, i just started trying right then. Everything has been a race against time and sometimes youre not grown enough. And this stuff? I was just trying to improve my digital literacy since thats good for science. I hardly trust myself and my career because Im stuck at a desk trying to solve basic...very basic computer problems. the F(L)OSS stuff didn't meet all of our critieriaHover image#4. And then youre trying to self correct, which is the basist of el camino. But in reality we never talk about trajectory superficially OR in a true learning-trust kind of convo. And all the while Newtons thrid law is looming over you > 101 figurative ways....I mean.. I dont understand how the combustion engine works. The only things I have solid knowledge or opinions of are from heresay about macro/micro nutrition, metableism, and kitchen econ. WeHover image#5. But God, youre cute in glasses... but youre way too soft shopHover image#6. Im helpless. Its funny for the first year or so... and then this stuff just gets dry, old, and toxic... like everyone else out there. Why cant you be someone positive anymore? around until something feels, rightHover image#7. I hate sitting this much but I can see the team better from here. rather than use objectiveHover imageI was always an unusual girl. My mother told me I had a chameleon soul, no moral compass pointing due north, no fixed personality; just an inner indecisiveness that was as wide and as wavering as the ocean. metrics about application usabilityHover imageGee, thanks!. IfHover image#8. If is an important word. And I can barely keep promises to my family, friends, and bosses. But here is what Id picture if I was responsible. F(L)OSS was so good, it wouldn't be freeHover imageObligatory Tim 'n Eric meme rightHover imageOhBoy.webp? It just feels saferHover imageHerp.jpeg when we can pay a companyHover imageBraaaaaaiiinsss to tellHover imageThanks, Id love 1000 high-quality lead compounds if you would. usHover imagePhilosoraptor On Evil K0rpos what the answers areHover imageHeHe HaHa! - some dwarf with a gun, probably.

We'reHover imageYou know the rules and so do I /s alsoHover imageProfessionalism 'n trade veryHover imageNight_at_the_ROX-bury.png scientificHover imagenotices... | Brrawghh! tooHover imageHow 2 Sciens MLG x-DropTheBasse-X. We experimentHover imageBoooom! ... wait... way too soon... with decreasingHover imageuw0t m8 number of replicatesHover imagetest.jpg we useHover imageSee, we measured it once but was below and above the average... during screeningHover imageJust sitting here waiting.... It's actually very methodicalHover imageMFW replication crises are in the news.... We make sure to use conceptsuhhhh... that make sense to our operations overloardsHover imageUHHHHH.... like 'budgetHover imageI was told there'd be budget priorities...', 'amortizedHover imageThe math was pretty cool...', and 'assetHover imagewell.. damn...' to describe what it is we do for themHover imageTheres art and theres science.. generic caption idgaf.... And sometimes we give them back some of the money from 'research and development' whenever we can. God knowsHover imageMLG bizness x-0nlyProphits-in-AltCoin-x-$uck@lmao-X they can invent drugs faster than we canHover imageProfessionalism and traaaaaddddeee. xXxKYS.htmlxXx, so we should let them claim the credit for tightening the beltHover imageHonstly, I'm still a wannabe. Have you ever wanted to be something like real bad, but didnt understand how to get there? Or even that the philosophy and mantras parroted at the start manifest in much different ways when it comes to organizing, flexility, and process? Every journey is always described as 'bottom to the top' in some hierarchical journey.

SeeHover imageSure it looks delicious the thing aboutHover imageThere is no regularization screeningHover imageNo concept of precision, accuracy, or the role of repitition in science? Roll your own! is that youHover imageWhen the late night star understands favoritism in screening better than some... don't needHover imageEasy, guys... I put my pants on, just like th rest of you, one leg at a time. Except once my pants are on, I make good choices based on data... /s all the data you generate, rightHover imageLet me get this straight... you want to increate the number of candidates per dollar from a screen... by reducing the replicates to one?? Only 1% of the ideas in research work. So lOgiCally if you reduce the number of replicates by 50%Hover imageKitty cat likes our chemistry, you take away most of the expense from stuff you didn't care about anyways...Hover image... still relevant, the 99%. The 99% is all junkHover imageTrue negatives are important for a model. And need to be measured precisely. that doesn' provide useful... information... or serve a purpose of controls.... so we don't need to be that confidentHover imageIgnorance and sensitivity! I mean.... confidence! about the majority (99%) of our measurements. Or the 1% either. In the end we'll just keep screening like robots until we find something about our magicHover image number cutoffHover imagehmmm... and then it either works or it doesn't! Don't worry about optimizing metricsHover imageOne does not, simply. like cost per true positive at all IRL or the reproducibility of some enrichment screen. It's not pragmatic. We serve at the pleasure of our investorsHover imageSomething something ass aids..., not the patients /s.

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